Comparison of Unsupervised Home Self-collected Midnasal Swabs With Clinician-Collected Nasopharyngeal Swabs for Detection

A cross sectional study with 185 symptomatic patients, of which 41 had positive results.

Study participants were recruited from symptomatic outpatients’ health care workers presenting to drive-through clinics. Participants were provided test kits for unsupervised home self-collection of a mid-nasal swab. Home swab performance was compared with clinician-collected nasopharyngeal swabs, which were collected by medical assistants and nurses.

Compared with clinician swabs,

  • The sensitivity of home swabs was 80.0% (95% CI, 63%-91%) and respectively (Table). Cohen K statistic was 0.81 (95% CI, 0.70-0.93).
  • The specificity of home swabs was 97.9% (95% CI, 94%-99.5%).
  • Cohen K statistic was 0.81 (95% CI, 0.70-0.93), suggesting substantial agreement.

Unsupervised home self-swab collection was found to present several advantages, including accessibility outside of the health care system and minimizing personal protective equipment use.


McCulloch, D. J., Kim, A. E., Wilcox, N. C., Logue, J. K., Greninger, A. L., Englund, J. A., & Chu, H. Y. (2020). Comparison of Unsupervised Home Self-collected Midnasal Swabs With Clinician-Collected Nasopharyngeal Swabs for Detection of SARS-CoV-2 Infection. JAMA Network Open, 3(7), e2016382-e2016382. doi:10.1001/jamanetworkopen.2020.16382